tau protein การใช้

• Association and stabilizing activity of tau protein depends on its phosphorylated state.
• Tau protein is a highly soluble microtubule-associated protein ( MAP ).
• Aggregation of these abnormal tau proteins correlates directly with pathogenesis and disease progression.
• Tau proteins interact with tubulin to stabilize microtubules and promote tubulin assembly into microtubules.
• Phosphorylation has been reported on approximately 30 of these sites in normal tau proteins.
• Through its isoforms and phosphorylation tau protein interacts with tubulin to stabilize microtubule assembly.
• Bezafibrate has been shown to reduce tau protein transgenic mice having human tau mutation.
• AD is also considered a tauopathy due to abnormal aggregation of the tau protein.
• Accumulation of tau protein is associated with tauopathies.
• Neuro
  鸼rillary tangles are collections of hyperphosphorylated tau protein associated with microtubules found within neurons.
• Tau protein isoforms are created by alternative splicing of exons 2, 3 and 10.
• The degradation products control transcription factors, which lead to the expression of a tau protein.
• This is due to the dysfunction of dephosphorylation mechanisms at specific amino acids on the tau protein.
• Tau proteins constitute a family of six isoforms with the range from 352-441 amino acids.
• Recent research suggests that FKBP52 may play a role in preventing the Tau protein from turning pathogenic.
• High levels of tau protein in fluid bathing the brain are linked to poor recovery after head trauma.
• Tau proteins can aid in the stabilization of microtubules by binding to the microtubules, protecting them from microtubule serving proteins.
• In Alzheimer's disease research, the AT8 antibody has proven to be an early indicator of tau protein pathology.
• The presence and accumulation of tau proteins found in the five living players, are associated with Alzheimer's disease.
• Do not say : " When normal phosphorylation is interfered with by mevalonate blockade, our cells increase the production of Tau protein.